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Aeron also offers a non-invasive assessment of bone turnover, the Pyrilinks-D (deoxypyridinoline) urine test, as an indication for and monitor of estrogen replacement therapy for osteoporosis. In combination with bone density measurement, rates of bone turnover are important predictors of the risk of fracture and the efficacy of therapy. The use of bio-identical hormone replacement and natural supplements continues to be a major focus of research at Aeron.