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Crowne Plaza St. Louis-Clayton Hotel , situated in beautiful downtown Clayton, Missouri. Our hotel is centrally located in the heart of St. Louis’ most prestigious business district and is only 15 minutes from Lambert – St. Louis International Airport. IHG Rewards Members are welcomed. The Crowne Plaza St. Louis-Clayton Hotel is conveniently surrounded by many of St. Louis’ finest restaurants, bars, boutiques and galleries. We are proud to serve our neighboring Forbes & Fortune 500 corporations including Armstrong Teasdale, Barry-Wehmiller Companies, Commerce Bank, Enterprise Holdings, Furniture Brands, JP Morgan Chase, Kindred Healthcare, PNC Bank and Wells Fargo to name a few.