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Picayune Drug Co. is a community based retail pharmacy and durable medical equipment provider offering our customers a wide range of medical needs. We are one of the first businesses to become established in the town of Picayune. Picayune Drug Co. first opened its doors in 1903 and we still remain in the original location in the heart of Picayune. Picayune Drug Co. is a family owned and operated, independent pharmacy, that is privately owned and operated by Andrew L. Failla, RPh and his wife, Brenda B. Failla, RN. Come see us today!