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At Acorn, we produce our culture material by submerged (deep-tank) fermentation under aseptic conditions. Major drug companies use this same process for antibiotic fermentation because it produces pure, clean cultures. Many other culture manufacturers do not operate their production processes aseptically. When the wanted organism is grown, many other organisms grow along with it. Some of these unwanted organisms are harmless. Others, however, may be positively harmful or dangerous. And products grown in a non-sterile environment often vary widely in content from fermentation to fermentation. One batch may be good but another terrible. The submerged fermentation method allows Acorn to produce high potency products under rigid control. It is a far more expensive procedure than is used to produce many competing products. However, when we specify that a product contains a certain number of a particular organism you can be sure it meets exactly those standards. Acorn plate counts never include adventitious organisms. And our products are certified free of both Salmonella and E. coli.