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In February 2001, Shionogi USA, Inc. was established as a subsidiary of Shionogi & Co., Ltd., in order to build a stronger international presence for one of the leading global Japanese pharmaceutical companies. Shionogi USA, Inc. serves as a primary vehicle for Shionogi & Co., Ltd.'s overseas development, bringing innovative compounds originated in Shionogi Research Laboratories to the US and Europe for clinical development. Shionogi USA, Inc.'s current development activities take place independently or in partnership with other pharmaceutical companies (see Shionogi-GlaxoSmithKline JV). As these development candidates progress, Shionogi USA, Inc. expects to expand its corporate infrastructure to support the sales and marketing activities that are necessary to commercialize medicines in the US. Our eventual goal is to become a fully integrated pharmaceutical presence in the US.