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Colorado Biolabs, Inc. was founded in 1997 with a plan to develop and market Proferrin ® , an oral iron supplement made from heme iron polypeptide (HIP). Our proprietary process results in a superior oral iron product that provides an optimal amount of HIP in a single tablet. Proferrin ® was introduced in 2001 and contained 7.5 mg. of elemental iron as HIP. Proferrin ® ES was introduced later that year with 12mg. of elemental iron. It quickly became the preferred product. Proferrin ® Forte was introduced in 2003 when folic acid (1 mg) was added to the formulation. Proferrin ® brand iron supplements provide many benefits over all other oral iron supplements. The heme iron polypeptide (HIP) in Proferrin ® delivers the iron in the naturally occurring heme molecule. Heme is manufactured in all mammals and is the key oxygen-carrying component in red blood cells. Heme is a major source of absorbed iron for humans, and it is normally and naturally ingested by consuming meats and meat products like beef, chicken, and pork. The fact that HIP is a "food" gives it a significant advantage over other iron supplements, because (as a food) heme has superior absorption* characteristics that are not altered by taking the tablets with food. A study was performed at the University of Colorado that compared taking 20 mg. of elemental iron as HIP as opposed to taking 20 mg. of elemental iron as ferrous fumarate with a standard meal. The study demonstrated that HIP increased serum iron levels 23 times greater than ferrous fumarate on a milligram-per-milligram basis1. Additionally, ingesting heme iron does not cause the high GI side effect profile associated with the other "inorganic" or "ionic" oral iron supplements. Both Proferrin ® ES and Proferrin ® Forte are currently available in the United States. Proferrin ® is also available in Canada (11 mg only). If you would like additional information about Proferrin ® ES, Proferrin ® Forte or heme iron polypeptide, please review the clinical studies and bibliography on this web site or call our headquarters at (888) 442-0067. * This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.