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Sinclair Research Center (Sinclair) is a miniature swine production facility and a contract research organization. Sinclair specializes in in-life preclinical efficacy testing and the production of animal models. In fact, Sinclair is the only private company primarily involved in large animal model development. Sinclair has contributed or is experienced in a number of animal models available to our clients, namely: Peripheral and Coronary Devices Evaluation, Spontaneous Ventricular Septal Defect (VSD), Diabetes type 1 and 2, Obesity, Atherosclerosis, Osteoporosis (4 models), White Hairless Miniature Swine for Dermal Studies, Spontaneous Regressing Malignant Melanoma, MHC Defined Lineages for Transplantation, Orthopedic Modeling and Surgical Modeling. Sinclair is proud to announce the acquisition of a high-power fluoroscope with cardiovascular support. We are now supporting the evaluation of peripheral and coronary devices, cardiac ischemic models, and local drug delivery evaluation. Sinclair is constructing a complete cardiovascular program for device, drug, and diet evaluation. In 2002, Sinclair acquired the Charles River Laboratories miniature swine colonies and the Maine production facility. This strategic acquisition has created a number of possibilities for scientists. To accommodate the growth of Sinclair, and to improve the quality of the research and production facilities, Sinclair purchased 200-acres near Columbia and built a state-of-the-art research and animal production complex that has more than twice the capacity of the original UMC site and continues to grow. The facility was completed in the fall of 2004 and is fully operational. Sinclair also operates the Maine Yucatan production facility acquired from Charles River Laboratories, and has instituted improvements and expansions in that facility as well. Sinclair complies with a number of agencies. We are USDA licensed as a breeder (43-R-2499) and research facility (43-R-0109). We are AAALAC accredited and GLP compliant. The animal care and veterinary program is in compliance with the Guide for the Care and Use of Laboratory Animals. Sinclair has an Assurance Statement filed with PHS.