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Isis Pharmaceuticals, Inc. (Isis) is a biopharmaceutical company engaged in antisense technology, exploiting a drug discovery platform to create a pipeline of drugs. In addition to its antisense programs, the Company maintains technology leadership beyond its core areas of focus through collaborations with Alnylam Pharmaceuticals, Inc., Ercole Biotech, Inc. and Regulus Therapeutics LLC, its joint venture focused on microRNA therapeutics. It explores the technology beyond antisense with additional opportunities in infectious disease identification through its Ibis Biosciences, Inc. subsidiary, and in the discovery and development of aminoglycoside and aptamer drugs though its technology partners, Achaogen, Inc. and Archemix, respectively.(Source: 10-K)