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Ortho-McNeil markets TOPAMAX-(topiramate) Tablets and TOPAMAX-(topiramate capsules) Sprinkle Capsules, which is indicated as add-on therapy for adults and pediatric patients ages 2-16 years with partial onset seizures or primary generalized toni-clonic seizures. In clinical trials, in combination with traditional AEDs, the most common side effects associated with TOPAMAX in pediatric patients included excessive drowsiness, loss of appetite, fatigue, nervousness, difficulty with concentration/attention, weight decrease, aggressive reaction and difficulty with memory. The safety and effectiveness in patients younger than two have not been established. In adults, the most common types of side effects were somnolence, dizziness, coordination problems, speech disorders, psychomotor slowing, abnormal vision, difficulty with memory, sensory distortion and double vision. Ortho-McNeil also markets pharmaceutical products in several therapeutic categories including infectious diseases, central nervous system, wound healing and women's health.